GLYCOPROTEIN:
From the table 4 depicts, the levels of stress
induced rats in group II show us the decrease changes in the levels of Hexose
and hexose amine levels. The control group of rats remains near the same in our
condition of stress the levels of glycoprotein in group II group not much affected
by stress induced paradigm.
In
the study associated to decrease in
glycoprotein, which evidence our study is that intracellular matrix protein
associated glycoprotein and decrease expression in postmortem of patients with
depressive disorders(Fatemi et al.,2005).
Glycoprotein are found inside every
cell and used by the body for various other purpose including building enzymes,
hormones, immunoglobulins and antibodies. The sugars found in glyconutrients also
enhance functions of the brain and nervous system, from memory and sleep to
anxiety and depression.
TABLE 4
The
activities of Glycoprotein level of myelin of fore, mid and hind brain of
control and experimental Rats.
|
PBC
|
GROUP I
|
GROUP II
|
||||
|
FB
|
MB
|
HB
|
FB
|
MB
|
HB
|
|
|
HEXOSE
|
143.6 ± 14.8
|
118.6 ± 12.8
|
93.6 ± 10.8
|
164.4 ±12.86***a
|
146.4 ± 10.86**b
|
128.4 ± 8.86*c
|
|
HEXOSAMINE
|
135.2 ± 10.08
|
122.4 ± 9.12
|
115.8 ± 8.16
|
151.22 ±10.8*a
|
141.24 ± 9.7*b
|
131.26 ± 8.6*c
|
|
FUCOSE
|
87.46 ± 8.67
|
80.42 ± 7.46
|
73.38 ± 6.25
|
115.15 ±10.52
|
109.12 ± 9.44***b
|
101.09 ± 8.36
|
|
SIALIC ACID
|
204.5 ± 21.32
|
194.7 ± 19.28
|
184.9 ± 17.24
|
235.9 ± 22.20*a
|
225.8 ± 20.18*b
|
215.7 ± 18.16**c
|
Values are expressed as mean ± SD (n=6).
PBC – mg/g of tissue.
Statistical representation was expressed as P<0.05
*a FB of group I compared
with Group II
*b MB of group I
compared with Group II
*c HB of group I
compared with Group II
The
activities of Hexose level of myelin of fore, mid and hind brain of control and
experimental Rats.
Values are expressed as mean ± SD (n=6).
PBC – mg/g of tissue.
Statistical representation was expressed as P<0.05
*a FB of group I
compared with Group II
*b MB of group I
compared with Group II
*c HB of group I
compared with Group II
Graph
-8
The
activities of Hexosamine level of myelin of fore, mid and hind brain of control
and experimental Rats.
Values are expressed as mean ± SD (n=6).
PBC – mg/g of tissue.
Statistical representation was expressed as P<0.05
*a FB of group I
compared with Group II
*b MB of group I
compared with Group II
*c HB of group I
compared with Group II
The
activities of Fucose level of myelin of fore, mid and hind brain of control and
experimental Rats.
Values are expressed as mean ± SD (n=6).
PBC – mg/g of tissue.
Statistical representation was expressed as P<0.05
*a FB of group I
compared with Group II
*b MB of group I
compared with Group II
*c HB of group I
compared with Group II
Graph
-10
The
activities of Sialic acid level of myelin of fore, mid and hind brain of control
and experimental Rats.
Values are expressed as mean ± SD (n=6).
PBC – mg/g of tissue.
Statistical representation was expressed as P<0.05
*a FB of group I
compared with Group II
*b MB of group I
compared with Group II
*c HB of group I
compared with Group II
Cell surface glycoconjucates plays a role in
cell adhesion and conjucation. The electrophoresis pattern of tissue
glycoprotein in the control and experimental rats were studied. From the figure
it is evident that stress induced tissue glycoproteine express lower intensity
as compared to control. The other control groups shows increase intensity of
bands compared to stress induced group. From this we infer that neuronal
membrane is altered and shows decrease glycoconjucates carbohydrate residue of
glycoprotein in stress induced rats. Reelin a glycoprotein, this is an
important matrix-associated glycoprotein which shows decrease expression in
postmortem frontal cortex of patients with pshychiatry disorders (Fatemi et
al., 2005).
SDS-PAGE
PATTERN OF MYELIN GLYCOPROTEIN
PLATE 2:
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