RESULT AND DISCUSSION -INVIVO ANALYSIS

INVIVO ANALYSIS:

HISTOPATHOLOGICAL STUDIES:

Stress becomes the most important single factor in virtually every disease state. In response to any of a variety of stressors, major and prolonged depression is accompanied by morphological changes in the brain, a decrease in the volume of midbrain and moderate changes in fore and hind brain regions.

During the period of chronic stress, the adrenal gland stimulate excessive exposure of glucocorticoid in the midbrain regions can be directly toxic to neurons or can increase the neurotoxicity of various hippocampus insults (Lee et al., 2002).

Stress induced structural changes in brain region such as the hippocampus may have clinical ramifications for disorders like depression and posttraumatic stress disorder (McEwen, 2000). Thus, stress may represent an important factor in anxiety and depression.

Few normal cells present in edematous cortical region with scattered damaged neuron compared with normal architecture of brain observed.

It may due to the depression, proceeds to some sort of abnormal neurodevelopment

Figure: 1

A

B

C

D

E

F

                         

                                                                                                                                                                                            Figure  1: Histopathological tissue section  from fore, mid and hind brain of rat stained with H and E  and histogram in 40X                                              

A, B, C (CONTROL):      Normal architecture of brain Fore, Mid, Hind brain was observed.

D, E, F (INDUCED):        Few normal cells present in edematous cortical region with                                                                                 scattered damaged neuron.